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List Aromatic Amines Used in Industry and Discuss Their Toxicological Effects

Aromatic amines are amines with nitrogen atom which is linked to an aromatic ring. The alkalinity of amine is decreased due to the aromatic ring and depends on its substituents. Aromatic amines are widely used in dyeing industry as a starting material for manufacturing of different types of azo dyes, such as methyl orange, sunset yellow, ponceau colors. As aromatic amines take part in many chemical reactions, they are used in chemical industry, for example for manufacturing of petrol and diesel fuel, varnishes, and antioxidants. In this case aromatic amines are used as fuel additives. Besides, aromatic amines are widely used in some metal-coating multifunctional compositions for motor, transmission and industrial oils. Some aromatic amines can be find application in plastic, textile and rubber industries. They are used in production of cloths, rubber, plastics. Aniline, one of the most widely spread aromatic amines, can be converted into sulfanilic acid which is considered to be the parent compound of some sulfa drugs. The following aromatic amines are used in industry:

  • Acridine;
  • Aniline;
  • Pyridine;
  • Quinoline;
  • Beta-naphthalene;
  • Benzidine;
  • Diaminodiphenylmethane and others.

The toxicological effects of the above mentioned aromatic amines are rather dangerous and can cause harm to human health. Aromatic amines used in industry can cause:

  • Bladder cancer;
  • Ureter cancer;
  • Renal pelvis cancer;
  • Liver damage of the cholestatic type;
  • Jaundice outbreak;
  • Methæmoglobinæmia and cyanosis;
  • Malignant tumours.

It is known that in most cases the latent period can last 15-20 years. Besides, aromatic amines contaminate air. (Darelanko & Hollinger, 2001, p.71)



Derelanko, M. & Hollinger, M. (2001) Handbook of Toxicology, Second Edition. Informa Healthcare.